Improvement of Antibody Activity by Controlling Its Dynamics Using the Glycan–Lectin Interaction

Antibody dynamics on membranes, such as endocytosis and clustering, are vital in determining antibody functions. Yoshiyuki Manabe, Kazuya Kabayama, Koichi Fukase et al. proposed a new approach to modulate its function. In their Communication (e202304779), the was conjugated with galactose-containing N-glycan, internalization suppressed by interaction galectin-3, leading enhancement of complement-dependent cytotoxic (CDC) activity. The glycan–antibody conjugate might provide an alternative strategy for enhancing